Dr. Sergiy Perepelytsya

• Physics of biological macromolecules
• Structure and dynamics of the ion-hydrate environment of DNA
• Interaction of active molecules and metals with the DNA double helix

• Terahertz dynamics of water molecules and counterions in the hydrated shell of the DNA double helix.
• Conformational dynamics of natural polyamines interacting with the DNA double helix.
• Dynamics of DNA in the condensed state and in the conditions of the viral capsid.
• Formation of stable complexes of drug molecules with DNA.
• Structure and dynamics of DNA in the nucleosome.
• Structure and dynamics of nanowires based on metallized DNA.
• DNA in an external electric field.
• Conformational mechanics of special forms of DNA and RNA.

• Methods in Molecular Biophysics
• Computer simulation of biological macromolecules
• Biophysics of macromolecules

• Vasiliu T. , Mocci F., Laaksonen A., Engelbrecht L., Perepelytsya S., Caging polycations: Effect of increasing confinement on the modes of interaction of spermidine3+ with DNA double helices, Frontiers in Chemistry (2022). https://doi.org/10.3389/fchem.2022.836994
• Perepelytsya S. , Uličný J., Volkov S.N., Molecular Dynamics Study of the Competitive Binding of Hydrogen Peroxide and Water Molecules with DNA Phosphate Groups, Eur. Biophys. J. 50, 759 (2021). DOI: 10.1007/s00249-021-01522-8
• Zdorevskyi O.O., Perepelytsya S.M. Dynamics of K+ counterions around DNA double helix in the external electric field: a molecular dynamics study. Eur. Phys. J. E 43: 77, (2020). doi: 10.1140/epje/i202
• Perepelytsya S., Uličný J., Laaksonen A., Mocci F. Pattern preferences of DNA nucleotide motifs by polyamines putrescine2+, spermidine3+ and spermine4+. Nucleic Acids Research. 47, 6084 (2019).
• Perepelytsya S. Hydration of counterions interacting with DNA double helix: a molecular dynamics study. J. Molecular Modeling, 24, 171 (2018).
• Perepelytsya S.M., Volkov S.N. Conformational vibrations of ionic lattice in DNA: Manifestation in the low-frequency Raman spectra. J. Mol. Liq. 164, 113-119 (2011).
• Perepelytsya S.M., Volkov S.N.. Intensities of DNA ion-phosphate modes in low-frequency Raman spectra. Eur. Phys. J. E 31, 201-205 (2010).
• Perepelytsya S.M., Volkov S.N. Counterion vibrations in the DNA low-frequency spectra. Eur. Phys. J. E 24, 261-269 (2007).
• Bulavin L.A., Volkov S.N., Kutuvy S.Yu., Perepelytsya S.M.. Observation of the DNA ion-phosphate vibrations. Reports of National Academy of Science of Ukraine 11, 69-73 (2007).